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LOOKING YOUNGER AND FEELING YOUNGER
By Dr LE. Dorman

"Happiness is good health and a bad memory."
-Ingrid Bergman           

CHAPTER 5

As an osteopathic physician, I have been educated 'in techniques of treating a variety of influences on disease with a focus on structural manipulation. Examples of osteopathic procedures include the realignment of the cranium in a young child to assist in overcoming growth retardation and the effects of spinal manipulation on relieving knee pain. For me, understanding these and related concepts comes with the inherent acceptance that all areas of the body are interactive and while we may choose to isolate and treat diseases symptomatically, we will attain better results when we treat the body as a whole. As I continually strive to practice medicine with this as my guideline, I am assured that I am on the right path.

In the practice of nutrition and preventive medicine, I have observed unsurpassed improvements in a variety of disease states for which there otherwise seems to be no effective treatment.

I have seen the disparity in the response of patients who are treated similarly with nutrients and medication, but whose dietary and exercise habits differ. The results of long term exposure to a diet high in fat and refined carbohydrates are clear: insulin resistance, high blood pressure, increased body fat, fatigue, heart disease, high cholesterol, arthritis, and resistance to treatment. In researching growth hormone, I found these to be the precise areas that consistently improve with GH therapy.

I have long recognized the role of hormone replacement in deterring the aging process, and it has become clear to me that restoring growth hormone and IGF-1 ought to be a primary focus in HRT. In the replacement of any hormone, it is important for me to use a natural hormone rather than a synthetic one and to mimic the body's own production of that hormone in terms of quantity and frequency of release. Considering these parameters as part of a GH therapy that I would implement into MY practice, I realized that it made a lot more sense to use a natural secretagogue rather than injections for the following reasons:

  • Natural: Secretagogues stimulate the body's own growth hormone to be released, whereas injections utilize
                  synthesized growth hormone.

  • Quantity & Frequency: Symbiotropin enhance, the existing pulsatile secretions of GH, with injections take the
                                        place of these secretions.

  • Conversion to IGF-1: This process is affected liver & pancreatic function, which are address by pharmaceutical
                                     sugars in Symbiotropin. Injections do not address this.

  • Side Effects: Symbiotropin consists of all natural ingredients, reducing the likelihood of side effects. Injections can
                         cause many side effects, especially at higher doses.

  • Compliance: Many patients find it difficult to inject themselves daily. Symbiotropin is delivered in a drinkable form.
                         Injections must also be kept at low temperatures until use; this is not always practical.

  • Cost: GH injections cost $800 - $1,200/month.
             Symbiotropin costs about $125.00 - $200.00/month.

 

The Insulin Hormone Replacement Connection

While most physicians today are familiar with recognizing and treating hormone deficiency, there is generally a disregard for the complex interaction that all hormones have with one another. Insulin is a hormone that greatly affects the secretion and response to estrogen, growth hormone, progesterone, and thyroid hormone-and it is controlled largely by the diet,
but not entirely. The aging process results in a declining ability to manage insulin and other hormones. Hence, the ideal anti-aging hormone therapy would include insulin management in a way that addresses insulin production and receptor sites. If insulin is not regulated, much higher dose of hormones-like estrogen-must be used to attain the desired response. This concept applies to the interaction of most replacement hormones that I am familiar with-the broader range of hormones that are being replaced, the lower the required dose for each of them.

For the most part, hormone replacement therapy (HRT) has proven to be quite effective in reversing symptoms associated with deficiency, but there are a significant number of patients who have a limited response. A good example of this is a female patient in her mid-forties who had a full hysterectomy in her early thirties and had been suffering from severe hot flashes, depression, and painful vaginal dryness. By the time she came to me, she had already been treated by many physicians with nearly every combination of hormones imaginable, but to no avail. By using natural hormones rather than the synthetic ones that she had been exposed to, we were able to improve her condition, but it seemed that we couldn't eliminate her symptoms entirely. Then we introduced Symbiotropin into her protocol. Within a few days she reported a complete disappearance of her depressive symptoms and a dramatic decrease in the intensity of her hot flashes.
Within two weeks she had completely overcome all of her symptoms that she had suffered from for so many years, including the painful vaginal dryness. Did this seemingly miraculous recovery occur solely due to stimulation of growth hormone and IGF-1? Not exactly.

The methods by which Symbiotropin has its action include insulin regulation and control of blood glucose, which are both essential to GH release. Excess insulin and blood sugar inhibit the ability of hormones like estrogen to get into the cell and perform their function. This type of resistance to hormone therapy is often addressed by using superphysiologic doses-which go beyond replacement of a deficient hormone. From clinical experience, patients who do not fully respond to physiologic doses of HRT have outward symptoms of blood sugar imbalance, including the following:

  • Difficulty getting from one meal to the next
  • Fatigue, especially in the mid-afternoon
  • Craving of sweets
  • Excessive carbohydrate intake
  • Dizziness and/or shakiness between meals
  • Awakening to hunger in the middle of the night
  • High or low blood glucose levels
  • Diabetes

Patients with these symptoms are gene candidates for Symbiotropin therapy.

Diabetic patients are easy to immediate response to Symbiotropin because glucose levels are monitored frequently patients have demonstrated remark stability within the first few weeks of is true even for those who are medic continue to have uncontrolled diabetes. I have observed patients who have ongoing problems with glucose levels that fluctuate daily, often reaching 250 - 350. One patient, a 64 year old male had worked with his endocrinologist for years, adjusting dosages and changing drugs, yet his blood sugar was consistently reaching 275 - 300. After 2 weeks of Symbiotropin, his blood sugar was peaking at 120; this response remained consistent to the extent that he is able to use lower doses of his medication while controlling his blood sugar in a way that previously seemed impossible.

The profound results that have been observed in controlling hyper and hypoglycemia are an interesting contrast to the known resistance to hGH injections that is normally experienced by these patients. As Jamieson has pointed out, healthy pancreatic function is necessary for the proper formation of IGF-1 -in addition, glucose and insulin must be circulating at low levels in order for GH to be released. Addressing insulin resistance and insulin production seems to be not only a necessary component of GH stimulation, but a profound means of controlling blood sugar as well. With insulin playing a central role in the management of so many different hormones, it's no wonder that we are observing so many far reaching effects on menopausal symptoms, high blood pressure, heart disease, and other areas.

Before we go on to examine various areas improvement that have been observed with Symbiotropin, it should be made clear that we set out to make these observations in the most objective manner possible. The patients were not instructed to monitor any symptoms that they had been experiencing at the onset of therapy. They were only told that their IGF-1 levels were found to be low, and that we would monitor changes in IGF-1 in response to Symbiotropin. I was amazed to find that patients were calling me within just a few days to report profound improvement in a variety of symptoms. They were reporting increased energy, flexibility, reduced pain from arthritis, and an overall improvement in the sense of well-being. The areas that I will focus on here are those in which I have observed consistent improvement. The following areas apply to diseases that afflict many people, and though I cannot suggest that Symbiotropin is a "cure" for these maladies-the results cannot be ignored.

 

Heart Disease & High Blood Pressure

My practice includes the use of EDTA chelation therapy with patients who have mild to advanced heart disease.
Most of these patients are working closely with a cardiologist and many of them have severely impaired cardiovascular function to the extent that they have difficulty with simple exercises like walking. Reducing the plaque in the arteries is helpful, but with an unconditioned heart they often cannot perform simple tasks without shortness of breath. The results of Symbiotropin have been profound in this area. While a large number of patients have reported improved energy, perhaps the most profound stories are of those with heart disease who are suddenly able to not only walk across the room without running out of breath, but who are able to begin more intense heart strengthening exercises as well.

Studies that we have referred to previously suggest that hGH injections elicit a significant improvement in cardiac output. This may be due to the supportive role that IGF-1 plays in strengthening muscle tissue, but the effects of Symbiotropin seem to go beyond this effect in ways that are not fully understood. For instance, many patients with impaired pulmonary function and emphysema have reported rapid improvements in lung capacity and subsequent increase in stamina.

A 63-year old male who is overweight and a heavy smoker with heart disease had undergone chelation therapy and experienced some improvement, but when he was given Symbiotropin he had a marked increase in strength, endurance, and breathing capacity to the point that he can exercise daily. He has experienced increased muscle strength and reduced body fat as well.

Although emphysema is not typically associated with heart disease, the results in this area are significant in evaluating the total effect in improving cardiovascular function. A 67-year old male with chronic bronchitis and emphysema was nonresponsive to other treatments, when he was given Symbiotropin he immediately experienced increased lung capacity, energy, and endurance. These results were not expected since I had not read any data indicating that other forms of growth hormone therapy had produced these results. Observations of, increased lung capacity have been consistent despite the variety of influences on impaired pulmonary function, including smoking, allergies, emphysema and bronchitis.

There are many influences on high blood pressure, including adrenaline, arterial plaque, and kidney function.
Most patients are able to control the factors that affect their high blood pressure, while some have uncontrolled high blood pressure regardless of medication. It is in these cases of uncontrolled blood pressure that we have observed significant improvement. One such patient was using a combination of blood pressure medications, yet it was not uncommon for his blood pressure to reach 170/130 on a daily basis. After just a few weeks of Symbiotropin, he was able to maintain consistently controlled levels of 120/70 to 130/80.

Angina can be a frightening experience and a hindrance to heart-strengthening exercises. A 64-year old patient with advanced heart disease and daily chest pain onset with even mild exertion reported complete cessation of chest pain within 24 hours of the first dose of Symbiotropin. I choose this among other examples of improvement in angina because it suggests mechanisms of action that go beyond strengthening of the heart muscle, which would normally occur over a much longer period of time.

 

Arthritis & Musculoskelatal Improvement

This is another area that I had not anticipated to find the consistent improvement that we did. Nevertheless, the results couldn't be ignored. Patients have reported flexibility that they had not experienced in over 30 years, with several patients describing themselves to have an easier time getting out of bed in the morning. Those with arthritis reported significant reduction in pain. Many were able to recover from muscular injuries and pain from exercise much more efficiently.
We observed increased range of motion in the joints and increased muscular strength. A few of my patients who had fibromyalgia, a condition that involves chronic muscular pain, had significantly reduced pain scores. The most fascinating and consistent reports were those of healing and reduced pain from old injuries. These include a patient who described pain in his shoulder that would wake him up at night and continue throughout the day-this 20-year old injury had caused constant pain that subsided after 8 weeks of Symbiotropin. An 83-year old man had a back injury that was more than
30-years old. He had such stiffness and pain that he could not bend over to tie his own shoes, but now he can touch his toes without bending his knees and without pain.

What are the common elements of these conditions and the changes that were observed? They all involve inflammation and degeneration, which both have many causative influences that may be affected by Symbiotropin. It is known that some forms of arthritis and fibromyalgia are directly affected by the integrity of the gastrointestinal lining.
As we mentioned in the chapter, The Facts, studies indicate that growth hormone and the amino acid L-glutamine
(an ingredient of Symbiotropin) are important factors in the growth and thickening of the digestive tract lining.
This may be an important mechanism of action in pain reduction due to reduce leaking of inflammation-promoting substances from the digestive tract into the bloodstream. In addition, enhancing the digestive tract lining improves
nutrient absorption, which may assist in healing of damaged tissues.

Nutrient absorption is not the end of the story. Once nutrients are absorbed they must be utilized in a way that will help to repair cells and the tissues that they support. Growth hormone is unique among hormones in that it stimulates growth by directly targeting tissues, rather than endocrine organs. The insulin-like effects of IGF-1 as well as the insulin regulating effects of GH therapy play an integral role in the growth and reparation of tissues. Insulin transports glucose, proteins, and fats into the cell where they are used for energy and cell replication. By improving insulin utilization, we inherently promote healing. When we add the complimentary effects of growth hormone and IGF-1, the results are truly amazing.

It should be noted that the mechanisms that are described here are a sharp contrast to the action of anti -inflammatory drugs (steroids and NSAIDS). These medications reduce inflammation, but at the expense of wearing away the digestive tract lining and breaking down collagen in the joints. They offer an effective and immediate reduction in pain, but they do not repair tissues. In fact, they work to accelerate damage to tissues that are causing inflammation -creating a long-term dependence and worsening of the condition. There are supportive nutrients that can supply the raw materials for rebuilding this damaged tissue, but without the proper hormonal stimulation results may be limited.

 

Insomnia

Best-selling books on melatonin have shed light on the importance of sleep in controlling the aging process. Melatonin, referred to as the sleep hormone, is produced according to a similar circadian rhythm as growth hormone, where they are both released primarily at night. Some melatonin researchers are now suggesting that some of the anti-aging benefits of melatonin may come from its growth hormone enhancing properties. Both hormones are produced in declining amounts as we age-to the extent that many elderly people have difficulty sleeping and do not have efficient rest.

Most patients, including those who didn't previously describe difficulty in sleeping, have reported improvements in their ability to fall asleep, stay asleep, attain deeper and more efficient sleep, and experience more vivid dreams. They have reported feeling more refreshed upon awaking and having more energy during the morning hours. We have not measured melatonin levels in these patients to determine a change, but there is clearly an improvement in sleep. From experience, melatonin supplementation produces mixed results-this does not seem to be the case with Symbiotropin, which seems to work consistently in this area.

Insulin regulation plays a role in sleep patterns as well. Hypoglycemia, or low blood sugar, tends to occur at night simply because we don't eat while we are sleeping. When blood glucose levels drop, adrenaline is released as a secondary energy source. As a stimulatory hormone, a release of adrenaline at night can result in a variety of outcomes, from initiating lighter and less efficient sleep, to causing night sweats and sleeplessness. The management of insulin that occurs with Symbiotropin may be a significant mechanism of action that helps to improve sleep by reducing the incidence of nocturnal hypoglycemia.

 

Weight Control

I refer to control rather that loss because we have observed consistent increase in muscle mass and significant decrease in body fat, which, together, do not always produce weight loss. This process often begins within the first week of Symbiotropin therapy where patients have experienced weight loss of up to 7 pounds. The majority of overweight patients maintain a loss of 2-3 pounds per week. At the same time, the increased strength, energy, and endurance allow them to perform higher intensity workoutsthereby increasing muscle mass and raising the base metabolism.

As is the case with so many other areas of improvement with Symbiotropin, insulin regulation plays a central role.
In our chapter on Diet & Exercise we will go into greater detail on things that you can do to enhance this process.
IGF-1 and growth hormone are both known to elicit lypolisis (fat burning) and building of muscle tissue.
Some ,nutritionists and doctors still subscribe to the philosophy that fat storage is based purely upon the difference between calories going in (diet) and calories going out (exercise). Although this is an important principal, many people find it to be frustrating and insulting. You don't have to look far (perhaps as far as the nearest mirror) to find a person who cannot maintain the body composition that they could previously, despite the fact that they have not changed their diet or exercise habits. Even worse, many people continue to store more fat even while consuming fewer calories and doing more exercise. This unfortunate process takes place largely due to the hormonal changes that occur with age.
The endocrine system is no longer maintaining the same metabolic rate. This can often, be observed by a decline in body temperature and/or reduced energy and endurance. By restoring growth hormone and IGF-1, we are not only directly restoring our ability to bum fat, but we are also helping to restore proper function of endocrine organs, like the thyroid, that maintain our metabolism.

 

Hair, Skin, and Nails

Growth hormone and IGF-1 stimulate the growth of hair, nails, and skin. Several patients have reported rapid growth of nails and hair, to the point that the have to visit the barber shop more frequently. Many have reported thicker and healthier hair and nails as well. But let's get right to the point-most of us want to know how to get rid of those wrinkles. This is a process that is more likely to occur with long term use and with the other supportive nutrients. However, we have observed significant reduction in wrinkles in men and women within as little as 4 weeks. I have seen patients in their 70's and 80's transform their complexion from gaunt, colorless, and wrinkled to plump, healthy, and smoother in a very short period of time. Yet, I have seen others who don't seem to show such dramatic signs of improvement. What is the difference?

Many of my patients are using nutritional protocols that include large doses of vitamin C, bioflavanoids, and amino acids like proline and lysine, which are components of collagen -the "glue" for skin cells that help to maintain firmness and strength. Other patients are not supplementing with these important raw materials for collagen synthesis and have had a history of smoking and excess sun exposure, which breaks down collagen. There appears to be a difference in the way that these two groups of people respond to Symbiotropin in terms of wrinkle reduction, but there may be other influences that are not fully understood. It will be interesting to see if, over a longer period of time, we will see more consistent smoothing of skin.

 

Sex Drive

Both male and female patients have reported improvement in libido and duration of intercourse. The response to sex hormones -like testosterone- are enhanced with GH therapy, which would explain is the increase in sex drive for both sexes. In addition, men will benefit from increased circulation and the effect that this has on maintaining erection.

 

Testing and Monitoring

At this point, Symbiotropin has only been used under the advice and supervision of a physician. It has been used only in patients who demonstrate IGF-1 levels below 350 with monitoring every 4 - 8 weeks. Our results have shown fluctuating IGF-1 levels in the first four weeks of use with increases of IGF-1 reaching over 200% and averaging over 18%. In the next four weeks of use, changes in IGF-1 tend to be stable peaking just over 100% and averaging 24%. By the twelfth week of use (the end of the first cycle) we have observed the most consistent symptomatic improvements and increases in IGF-1, with an average increase of over 30%, to date. Interestingly, we had a few patients that had temporarily reduced IGF-1 levels, but for the most part these patients still exhibited symptomatic improvement. In a clinical environment it is probably not necessary to test IGF-1 more frequently than before and after each 12 week cycle of Symbiotropin.

 

Average increase in IGF-1 throughout first 12 week cycle of Symbiotropin.

All patients included in this study had initial IGF-1 levels below 350. Several patients with higher IGF-1 levels, including athletes, were given Symbiotropin and reported marked improvements in strength-, stamina, and body composition.
The changes observed in many of these patients indicate that Symbiotropin may work by sensitizing IGF-1 and insulin receptors. For example, an avid runner in her mid-forties was maintaining IGF-1 levels of 403, but she exhibited signs of low growth hormone such as unexplained weight gain and fatigue. Within weeks of beginning Symbiotropin therapy, she began to lose significant amounts of body fat while improving her energy and stamina without a significant increase in IGF-1. Body builders who have previously used GH injections have reported more rapid increase in muscle mass and definition with Symbiotropin.

The results of patient self-assessments indicate symptomatic response to Symbiotropin within the first four weeks in all patients, with continued improvement between the fourth and twelfth week. Improved energy, endurance, and body composition were among the most frequently reported improvements within the first four weeks. New hair growth, restoration of hair color, thickening of skin, and disappearance of skin discoloration generally occurred between the eighth and twelfth weeks, with continued improvement beyond the twelve week term. It should be noted that the results of this patient self-assessment are not adjusted for areas that did not apply to each individual.

 

Patients % Reported Improvement with Symbiotropin

 
  Area of Assessment
 

Month Three
 
  Endurance & Body Composition  
  Muscle Strength 58%
  Muscle Size 42%
  Fat Reduction 68%
  Overall Energy 74%
  Exercise Tolerance 58%
  Exercise Endurance 68%
  Hair & Skin  
  Skin Texture 47%
  Skin Thickness 32%
  Skin Elasticity 26%
  Wrinkle Disappearance 37%
  New Hair Growth 47%
  Healing & Immunity  
  Healing of old injuries 26%
  Healing of other injuries 21%
  Healing Capacity 21%
  Back & Joint Flexibility 37%
  Resistance to Common Illness 47%
  Sexual Function  
  Sexual Potency/Frequency 32%
  Duration of Penile Erection 44%
  Frequency of Nighttime Urination 66%
  Mental Function  
  Mental Energy & Clarity 53%
  Emotional Stability 42%
  Attitude Toward Life 37%
  Memory 47%

Our experience with testing laboratories warrants the suggestion of using a laboratory that is experienced in the testing of IGF-1. This is a highly sensitive test in which blood samples must be kept frozen and handled properly. Allan Broughton, M.D., Director Antibody Assay Laboratories in Santa Ana, California (800-522-2611), established the first commercially available test for IGF-1 in 1979. My personal contact with him in the process of monitoring patients has been tremendously insightful as to the variability of IGF-1 assays when they are not performed in the proper environment.

We are publishing a continually updated guide for physicians who are using Symbiotropin. If your physician is not already familiar with this type of therapy, he/she may contact the publisher of this book for more information.

_______________________________

My fingernails have greatly improved. I have a healthier overall appearance, and my energy is greatly improved.

-M.M. (Female, Age 74)

_______________________________
 

 

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