Chaperone molecules assist in digestive tract absorption as well as
delivery to the proper receptors. Hence, it is necessary to define the
receptors that the active ingredients are targeting. All of the major
anterior pituitary hormones, except growth hormone, exert their primary
effect by stimulating target glands. GH exerts its effect on almost all
tissues of the body. This presents a significant challenge in going beyond
GH stimulation to elicit a response to GH and IGF-1 at the tissue level.
With the aging process, we not only experience reduced production of
growth hormone, but desensitization of receptors. One factor that affects
this desensitization is the blockage of these receptor sites by
environmental toxins and other substances. These receptors must be
unblocked in order to benefit fully from growth hormone therapy. This
"unblocking" process takes place under the influence of polysaccharide
chaperones molecules and specific plant compounds, which I describe as
The body often has alternative pathways of hormonal activity that are
responsive to natural plant-based substances, or Pharmafoods -several of
which are incorporated in Symbiotropin. These natural compounds, which are
on their way to becoming the medicines of the 21st century, assist the
body in healing itself in spite of mistreatment with various
hormone-mimicking chemicals that are now part of our environment.
Pharmafoods help to displace these unwanted chemicals and clear the way
for effective hormone replacement.
The pharmacologic effects of plant derived compounds are
well documented in both human and animal clinical trials. Some of
the mechanisms of action are still being elucidated. Two
definite pathways for the biological actions involve binding to
hormone receptor sites or to enzymes that metabolize hormones;
specifically, binding to steroid and prostaglandin dehydrogenase
enzymes. Structural similarities between various plant compounds
and their counterparts that are produced by the body enhance
Over the decades, I have continually use glandular extracts because
they provide therapeutic hormones in a natural form that the body can
recognize, respond to, and properly metabolize. Glandulars are not only
used as a hormone source, but as a support for similar tissues in our own
bodies. Research has shown that ingesting a tissue substance will
attenuate autoimmune responses to counterpart tissues in the body.
European doctors have many applications for glandular therapies, including
immune stimulation with thymus extract and reduction of inflammation with
pancreatic extracts. The emphasis on glandulars in European medicine led
me to study and train there in the areas of cryotechnology,
ultrafiltrations, xenogenic cell and tissue suspension, Iyophilisates, and
other methods of glandular tissue preparation. My studies in Europe
eventually led me to Hungary where I had the honor of working with the
brilliant scientist Tibor Kopjas, M.D.. Dr. Kopjas and I became deeply
involved in studying pancreatic extracts for their anti-inflammatory and
anti-tumor activities as well as their effect on hormone production and
My work in Europe led to an appreciation for the quality standards and
techniques involved in glandular therapies, which is not found in the
United States. European glandular products come from animals that are bred
solely for this medicinal purpose under highly regulated conditions that
:FIT control grazing, hygiene, feeding, breeding, and slaughtering.
These animals are recognized for their pharmaceutical purpose, hence they
are raised in a pharmaceutically controlled environment and carefully
processed to yield appropriate results.
Symbiotropin incorporates the use of anterior pituitary peptides that
have known effects on GH release.
Through advanced processing, the activity of these peptides is maintained
at a level that exceeds most live cell pituitary extracts. Originally, GHRH was the only known growth hormone releaser for which pituitary
receptors had been identified, it was thought that other releasers worked
indirectly on the pituitary. Since then, other GH releasing peptide
receptors, which still remain nameless, have been discovered on the
pituitary-indicating that there are other GH releasing hormones that have
not been discovered or named. Some of these peptides are currently under
investigation by pharmaceutical researchers, but they are usually injected
because of the tendency of fragile proteins to be broken down in the
digestive tract. If they only knew about Chaperone Molecules...
Growth hormone secretion is controlled by two hypothalamic
peptides: growth hormone releasing hormone (GHRH), which
stimulates it, and somatostatin, which inhibits it. Current
bioengineered secretagogues ignore these basic principals.
In working with hormone therapies in the early seventies, I developed a
prescription product called Aphrodex that was used to promote sex drive in
men. We yielded a much greater overall benefit by combining testosterone
with the herb yohimbe and the homeopathic nux vomica, than we could by
using any of the ingredients separately, hence we were able to use a lower
dose of testosterone, which may cause side effects when used in excess. As
a supplier of raw materials,
I had been synthesizing DHEA and other hormones from wild yams and I
became intrigued by the similarity of diosgenin in these yams to various
adrenal hormones. But after observing the powerful synergy of the
hormonally active botanical product and the isolated hormone in Aphrodex,
I was inspired to study and identify hundreds of previously unrecognized
botanical compounds that support and mimic the body's own hormones.
The study of plants and the therapeutic hormonal substances contained
in them led to a clearer understanding of hormone receptors in the body
and techniques for overcoming those that have become blocked. I also
observed the importance of processing these plants in a way that would
allow me to derive a standardized amount of a given substance without the
use of chemicals and without denaturing the enzymes and other components
of the plant. As much as I was discovering all of these "new" individual
active compounds, I also discovered the importance of preserving the
activity of all of the plant's components -so as not to second-guess
nature. This is not always an easy task; in fact, it takes a lot more time
and money than the methods that are used by most processors of herbs
Each plant has its own characteristics that must be taken into account
in processing and standardizing its active ingredients. Most raw material
suppliers of standardized herbs use a variety of chemicals, such as methyl
that denature some components of the original plant and are left in
significant amounts in the end product.
The people who consume these herbs often have no idea that they are
ingesting of Various toxic chemicals along with them. This doesn't work
for me. Not only do natural processes of concentrating botanicals, like
fermentation, allow the avoidance of chemicals, but they also preserve
active enzymes and allow the full therapeutic potential of the whole plant
to be realized.
In the development of Symbiotropin, I was led to the rain forest where
I had done extensive work with botanicals in the past and had established
valuable business connections. I discovered that a major pharmaceutical
company was using a local botanical product in the development of a
prescription secretagogue. This is not unusual as a large portion of
prescription drugs are derived from plant sources by first isolating one
active ingredient, denaturing it with a chemical side chain in order to
patent it, then performing extensive clinical studies and finally
submitting it, 21 million dollars later,
to the FDA for approval. Upon examination, I found that the "active"
ingredient was enhanced by the plant's other components. Further, we found
that a large amount of the activity of this ingredient was lost very
rapidly (within 2 hours) after harvesting. One of the active ingredients
in this plant is L-dopa, a potent stimulator of GH release. I had worked
extensively with L-dopa in the past as a consultant on its delivery.
L-dopa, used as an anti-aging drug and treatment for Parkinson's disease,
is poorly absorbed and must be taken in super-physiologic doses (thousands
of times what the body would produce in a day) in order to elicit a
response. At high doses, L-dopa can produce side effects, but at lower
doses it will stimulate GH release, improve mental performance, and
improve symptoms of Parkinson's disease.
As was the case in all of my experience with other botanicals, the
auxiliary substances in vicia faba, major enhanced
the activity and absorption of its naturally occurring L-dopa, so that it
would become a highly active secretagogue at
lower doses and without the side effects of prescription L-dopa.
The effectiveness of Symbiotropin in Parkinson's patients has not been
established through double blind clinical trials. However, there have been
reports of rapid improvement in tremors and overall sense of well being.
Growth hormone itself has produced improvements in Parkinson's disease;
with the dual action of L-dopa and other secretagogues in Symbiotropin,
and the lack of side effects, it's definitely worth a try for physician's
to observe its -affect on patients
who suffer from this devastating disease.
Studies conducted on the effectiveness of various amino acid stimulants
of growth hormone release have produced significant results. One test for
GH secretory potential is the arginine loading test, but very large
amounts are used-often intravenously. Other amino acids like ornithine,
lysine, and glutamine have produced mixed results. In the development of
Symbiotropin, I had to ask myself, "How could the response to these amino
acids vary to such a large extent?"
As it turns out, the study on L-glutamine that produced the most
significant elevation in GH administered the amino acid in a carbonated
drink solution. How could carbonation make that much of a difference in
the effectiveness of this amino acid in GH release? I had tested
effervescent delivery with L-dopa and other substances in the past and
found it to be highly effective in combination with Chaperone Molecules.
With carbonation, I had been able to produce rapid and efficient delivery
of sensitive compounds. In this case, I discovered that effervescent
delivery assists in the delivery of all amino acids in Symbiotropin so
that a greater and more consistent response can be derived with lower
There are many receptors for these amino acids, so getting them to the
right ones that stimulate GH release requires the use of Chaperone
Molecules. In addition to protecting and delivering these amino acids,
some Chaperone Molecules have insulin-regulating effects.
The importance of suppressing insulin in provoking GH release cannot be
overstated. Blood sugar and insulin inhibit the release of growth
hormone-this is a basic principle of the effectiveness of proper diet,
fasting and exercise in stimulating GH. While consuming sugar and other
carbohydrates in the diet will provoke insulin and inhibit GH release,
there are other sugars, referred to as pharmaceutical saccharides that do
not provoke insulin and are not metabolized as carbohydrates. In fact,
when the right saccharides are used they do just the opposite-they help to
regulate blood sugar and insulin. Some of these saccharides -like those in
Symbiotropin- have a sweet taste, which eliminates the need for artificial
or high carbohydrate sweeteners in flavoring the product.
I am not implying that insulin is the bad guy. In this highly complex
system, we need insulin to promote the benefits
of growth hormone. Studies show that GH fails to cause growth in animals
lacking a pancreas and it also fails if carbohydrates (insulin provoking)
are restricted from the diet. These studies reinforce our knowledge of
insulin as a necessary catalyst in GH response and demonstrate that high
levels of GH mean nothing in terms of results.
This is why I have concentrated on secretagogues, receptor site
modulators, insulin regulation, and liver enzyme enhancers rather than GH
As adequate availability of specific complex sugars, which only
work in conjunction with insulin, is necessary for GH to be
effective - it is interesting to note that bioengineered GH
injectables significantly lower insulin levels - what will the
long term effects be?
Upon examining the influences on GH and IGF-1, and looking further at
their complex interaction with other hormones that are centrally
controlled by the pituitary gland, it becomes apparent that the Methuselah
factor is contained within the pituitary system. There are many ways in
which we interfere with the proper functioning of this gland and other
endocrine organs- including improper diet and exposure to environmental
toxins that block receptors with their hormone-mimicking effects. At the
same time, we have the tools to optimize the dietary influence on
endocrine function and to unblock clogged receptors with the use of
natural compounds. When we supply the proper peptides and other compounds,
we "kick-start" optimal pituitary function, but we must not ignore
pituitary feedback mechanisms that are affected by other hormones and the
synergy that occurs when all hormones are addressed. It is a highly
complex system, but as we develop a full understanding of the elusive
Methuselah factor and its role in the maintenance of other hormones,
perhaps we are creating the choice to live for hundreds of years.
There are over 110,000 genes in the human body-one million partial gene
sequences have been identified. A new paradigm of pharmaceutical
innovation is focusing on new hormones and microbial genes to broaden and
accelerate the discovery of small molecule drugs. These new types of
medicines include gene therapy, protein therapy, and anti-sense therapies.
This method of small molecule drug discovery analyzes genes expressed only
in diseased or target tissues and is catalyzing the change from current
interdiction based medicine to gene based prevention.
With this research, we have gained access to therapeutic proteins that
replace deficient, missing, or damaged hormones. Some of these synthesized
peptides are currently under investigation as growth hormone
secretagogues, but their naturally occurring counterparts are contained in
Symbiotropin -an all natural GH secretagogue. Once we've identified the
right peptides to use, the most challenging obstacles in attaining
consistent and significant growth hormone release are absorption and
delivery to the proper receptor sites. Our team has researched and
developed an array of Chaperone Molecule delivery systems that address
gastric absorption, transport through the bloodstream, and attachment to
Research on various synthesized peptide secretagogues has produced
limited results in terms of IGF-1 formation and symptomatic improvement
because they do not address insulin regulation, hepatic formation of
IGF-1, or IGF-1 receptors. The pharmacologic effects of plant derived
compounds are well documented in both human and animal clinical trials.
These plant products possess structural similarities to endogenously
produced hormones, which enhance their affinity to hormone receptors and
steroid and prostaglandin dehydrogenases -making them effective adjuncts
to a variety of hormone replacement therapies.
As we more fully understand the decline of endocrine function in the
aging patient, we are recognizing the benefits of replacing a wider range
Of hormones-where lower doses produce a greater overall benefit. Central
to HRT response is management of growth hormone, insulin, and IGF-1. These
hormones potentiate the function of estrogen, testosterone, progesterone,
T3, and other hormones. Unlike these other hormones, which decline in
production with age, growth hormone continues to be produced in
significant amounts right into old age. The challenge in restoring
youthful levels of GH is not increasing production or injecting the
hormone itself, but releasing it from its sequestered state.
We now know how to unlock the gates that keep GH from circulating.
Studies on GH injections repeatedly demonstrate its effectiveness at
reversing signs of aging by improving body composition, increasing bone
density, reducing wrinkles, restoring hair, improving ,cardiac output,
reducing cholesterol, and improving 'vision and memory. In addition, our
clinical observations with Symbiotropin have yielded swift and significant
improvement in diabetes and high blood pressure -even in patients whose
symptoms were not able to be controlled with standard treatments. Insulin
and IGF-1 regulation is an integral part of managing many of the signs and
symptoms of aging.
As the FDA has recently approved growth hormone therapy for adults who
are deficient, which includes most people over the age of 40, we are
coming closer to the treatment of aging as a disease. In the replacement
of deficient hormones, it is incumbent upon us to use the safest and most
effective forms of these hormones. We are not limited to synthetic
hormones that the body does not recognize and metabolize as its own, and
which are associated with serious side effects. There are natural, safe,
and effective forms of estrogen, progesterone, testosterone, thyroid
hormone, DHEA, and other hormones that are identical to our own hormones.
These hormones are available in dosage forms that maximize bioavailability
and maintain effectiveness at physiologic doses. If our goal is to replace
why shouldn't we replace them naturally? What could be more natural than
utilizing the growth hormone that continues
to be produced by our own pituitary?
"The Cancer Center (1-800-720-8933; cancernet.com) has had first hand
confirmatory experience that Lissoni's reports from Italy asserting
efficacy for cancer treatment of combined interleukin-2 (IL-2) and
melatonin for many forms of adult cancer are valid. We believe
immunotherapy has now advanced to the degree that it is a lifesaving,
albeit less well studied, alternative to conventional cytotoxic
chemotherapy for many patients, including 'those with adenocarcinoma of
colon, pancreatic, breast, or lung origin. Once natural killer (NK)
lymphocytes have reached two or three times the normal level, we have
found [Symbiotropin] very useful to reduce the malaise often associated
with high blood levels of NK cells. We have instances where the addition
of [Symbiotropin] to (IL-2) therapy allowed us to restore debilitated
previous recipients of combination chemotherapy and allowed continued use
of (IL-2) and was associated with continued shrinkage of the cancer as
evidenced by successive drops in serologic markers such as CEA or
-R. Arnold Smith, Jr., M.D.
S. North Central Mississippi Regional Cancer Center
J.M., Female, Age 71
Began taking Symbiotropin and within one week lost three pounds.
Continued weight loss of three pounds per week throughout first cycle.
Patient reported increased energy, increased sense of mental well-being,
and deeper, more peaceful sleep. Skin appears softer and wrinkles are
diminishing. Age spots diminishing.
L C, Female, Age 48
History of severe cardiomyopathy and hypertension. Treatment with other
therapies provided some improvement, however cardiovascular function
continued to deteriorate. With Symbiotropin, her energy level immediately
increased. Shortness of breath decreased dramatically. She reports
increased energy and sense of well-being. Several of her medications have
been eliminated, including an ACE inhibitor; she continues to improve
B.N., Male, Age 63
Overweight, heavy smoker, with cardiovascular disease and pulmonary
distress. Had been treated with chelation therapy with some improvement.
Within four weeks of Symbiotropin therapy, breathing was greatly improved.
Lessened shortness of breath allows him to exercise to a much greater
extent. His blood pressure has been significantly reduced.
PC, Female, Age 46
Heavy smoker with total hysterectomy performed in early 30's with
subsequent hormone replacement therapy (HRT).
HRT did not control her hot flashes, sleeplessness, and anxiety. With
Symbiotropin therapy, she made dramatic improvement in these, and related
menopausal symptoms to the extent that she was able to reduce her dose of
estrogen and Progestin while remaining symptom free. In,' addition, she
reported improvement in other areas including improved energy.
G.F., Female, Age 65
History of being depressed and overweight. No long-term success with
previous treatments. After onset of Symbiotropin therapy, she experienced
weight loss of 2 pounds per week. Reports more energy and tremendous
improvement in mental outlook and anxiety.
L.J., Male, Age 55
Prior to Symbiotropin, this patient was overweight and experienced
reduced energy and sexual potency. After onset of Symbiotropin, he has
reported deeper and sounder sleep at night, which has eliminated his need
for napping during the day. He has improved stamina and is able to
exercise more vigorously. He reports significant improvement sexual
potency and has experienced continued weight loss.
"I weighed 300 lbs. and had been on insulin for almost five years... I
was using a total of 175 units of 70130 insulin everyday.. my doctor added
some glucophage... over the last two months I used Symbiotropin 5 nights a
week, lost 50 lbs, and dropped insulin requirements to only 10 units a
day! I'm going to keep using [Symbiotropin]... I was on glucophage before
& it didn't help. I know what is causing my improvement. Thank you!
Now I have an overall healthy appearance and feeling of well-being.
- L.M. (Male, Age 75)
I have been on the Symbiotropin for the past four months... I have so
much more energy now, I feel younger,
I look younger, I have less pains... I appreciate the difference it has
made in my life.
- R.B., Male
Thank you so much for suggesting the Symbiotropin. I have been on the
product for three months,
I have never felt better. My energy level is way up, my age spots are
gone, I feel great...