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IN PURSUIT OF THE METHUSELAH FACTOR
By Pharmacologist James Jamieson

"Each problem that I solved became a rule, which served afterwards to solve other problems."
-Rene Descartes, "Discours de la Methode"         

CHAPTER 4

"A substance that has the action of a hormone, but has not been purified & identified as a distinct chemical compound is called a factor."

As we have reviewed in chapter one, there has been an evolution of hGH from its original source as a glandular tissue extract to its existence today as a product of recombinant DNA synthesis. Paralleling this evolution, are pharmaceutical innovations that allow the manipulation of microbes to produce therapeutic proteins and the discovery of previously unrecognized receptors that affect GH release and conversion to IGF-1. Long before these discoveries, there were medicinal plants that we can now process and grow to be highly effective promoters of growth hormone secretion.
The story of the development of Symbiotropin, a natural secretagogue compound, is influenced by all of these aspects of pharmaceutical technology and begins with my work in developing prescription hormone products in the 60's and 70's.


Genetic engineering has been a catalyst in the discovery of therapeutic proteins to replace deficient, missing or damaged hormones.

As a third generation pharmacologist, my family had already established a reputation for producing effective hormone products from glandular and other sources. So it came as no surprise when I was approached by physicians and pharmaceutical companies in the early 70's to provide them with Human Chorionic Gonadotrophin (HCG). At the time, HCG was being used as a treatment for obesity, and although it was not approved for this application, it had become rapidly popularized because of its profound ability to cause significant weight loss very quickly. While overweight patients were losing 30 or more pounds per month without side effects, word spread and the demand for HCG began to exceed the" supply.

Like growth hormone, HCG was not convenient to use because it had to be injected, hence the cost was high and compliance was limited. No one had challenged the delivery of HCG as an injection because it was known to be broken down and rendered ineffective when administered orally. As a person who enjoys attempting to do the impossible, I set forth the challenge to produce the first effective HCG in an oral dosage form. I had to figure out a way to protect and stabilize this molecule throughout its entire route from the capsule, across the digestive tract, into the bloodstream, and finally to the targeted receptors. After researching the transport mechanisms of HCG, I began to experiment with various complimentary molecules that would serve to protect against hydrochloric acid and other destructive influences.
I eventually found the right substances to combine with HCG and created the first oral dosage form of this hormone.


GH is a Very Large Molecule, Which Is Unstable,
Expensive and Difficult to Manufacture

GH, or somatotropic hormone (SH) is a small protein molecule containing 191 amino acids in a single chain with a total molecular weight of 22,005.
Other posterior pituitary hormones, such as anti-diuretic hormone (ADH), vasopressin, and oxytocin, are polypeptides containing nine amino acids.

My work with HCG led to the discovery of over 300 molecules, now referred to as chaperone molecules, that I have used to facilitate delivery of hormones and other sensitive compounds. Most producers of pharmaceutical hormones use the attachment of chemical side chains to transcend absorption problems, often resulting in unwanted side effects.
On the other hand, the use of natural chaperone molecules allows hormones from plants and tissue extracts
to be absorbed and utilized in their natural state.

Eli Lilly is spending $60 million
for research on technology that
we already have!

Chaperone molecules assist in digestive tract absorption as well as delivery to the proper receptors. Hence, it is necessary to define the receptors that the active ingredients are targeting. All of the major anterior pituitary hormones, except growth hormone, exert their primary effect by stimulating target glands. GH exerts its effect on almost all tissues of the body. This presents a significant challenge in going beyond GH stimulation to elicit a response to GH and IGF-1 at the tissue level. With the aging process, we not only experience reduced production of growth hormone, but desensitization of receptors. One factor that affects this desensitization is the blockage of these receptor sites by environmental toxins and other substances. These receptors must be unblocked in order to benefit fully from growth hormone therapy. This "unblocking" process takes place under the influence of polysaccharide chaperones molecules and specific plant compounds, which I describe as Pharmafoods.

The body often has alternative pathways of hormonal activity that are responsive to natural plant-based substances, or Pharmafoods -several of which are incorporated in Symbiotropin. These natural compounds, which are on their way to becoming the medicines of the 21st century, assist the body in healing itself in spite of mistreatment with various hormone-mimicking chemicals that are now part of our environment. Pharmafoods help to displace these unwanted chemicals and clear the way for effective hormone replacement.


The pharmacologic effects of plant derived compounds are well documented in both human and animal clinical trials. Some of the mechanisms of action are still being elucidated. Two definite pathways for the biological actions involve binding to hormone receptor sites or to enzymes that metabolize hormones; specifically, binding to steroid and prostaglandin dehydrogenase enzymes. Structural similarities between various plant compounds and their counterparts that are produced by the body enhance this affinity.

Over the decades, I have continually use glandular extracts because they provide therapeutic hormones in a natural form that the body can recognize, respond to, and properly metabolize. Glandulars are not only used as a hormone source, but as a support for similar tissues in our own bodies. Research has shown that ingesting a tissue substance will attenuate autoimmune responses to counterpart tissues in the body. European doctors have many applications for glandular therapies, including immune stimulation with thymus extract and reduction of inflammation with pancreatic extracts. The emphasis on glandulars in European medicine led me to study and train there in the areas of cryotechnology, ultrafiltrations, xenogenic cell and tissue suspension, Iyophilisates, and other methods of glandular tissue preparation. My studies in Europe eventually led me to Hungary where I had the honor of working with the brilliant scientist Tibor Kopjas, M.D.. Dr. Kopjas and I became deeply involved in studying pancreatic extracts for their anti-inflammatory and anti-tumor activities as well as their effect on hormone production and modulation.

My work in Europe led to an appreciation for the quality standards and techniques involved in glandular therapies, which is not found in the United States. European glandular products come from animals that are bred solely for this medicinal purpose under highly regulated conditions that :FIT control grazing, hygiene, feeding, breeding, and slaughtering.
These animals are recognized for their pharmaceutical purpose, hence they are raised in a pharmaceutically controlled environment and carefully processed to yield appropriate results.

Symbiotropin incorporates the use of anterior pituitary peptides that have known effects on GH release. Through advanced processing, the activity of these peptides is maintained at a level that exceeds most live cell pituitary extracts. Originally, GHRH was the only known growth hormone releaser for which pituitary receptors had been identified, it was thought that other releasers worked indirectly on the pituitary. Since then, other GH releasing peptide receptors, which still remain nameless, have been discovered on the pituitary-indicating that there are other GH releasing hormones that have not been discovered or named. Some of these peptides are currently under investigation by pharmaceutical researchers, but they are usually injected because of the tendency of fragile proteins to be broken down in the digestive tract. If they only knew about Chaperone Molecules...


Growth hormone secretion is controlled by two hypothalamic peptides: growth hormone releasing hormone (GHRH), which stimulates it, and somatostatin, which inhibits it. Current bioengineered secretagogues ignore these basic principals.

In working with hormone therapies in the early seventies, I developed a prescription product called Aphrodex that was used to promote sex drive in men. We yielded a much greater overall benefit by combining testosterone with the herb yohimbe and the homeopathic nux vomica, than we could by using any of the ingredients separately, hence we were able to use a lower dose of testosterone, which may cause side effects when used in excess. As a supplier of raw materials,
I had been synthesizing DHEA and other hormones from wild yams and I became intrigued by the similarity of diosgenin in these yams to various adrenal hormones. But after observing the powerful synergy of the hormonally active botanical product and the isolated hormone in Aphrodex, I was inspired to study and identify hundreds of previously unrecognized botanical compounds that support and mimic the body's own hormones.

The study of plants and the therapeutic hormonal substances contained in them led to a clearer understanding of hormone receptors in the body and techniques for overcoming those that have become blocked. I also observed the importance of processing these plants in a way that would allow me to derive a standardized amount of a given substance without the use of chemicals and without denaturing the enzymes and other components of the plant. As much as I was discovering all of these "new" individual active compounds, I also discovered the importance of preserving the activity of all of the plant's components -so as not to second-guess nature. This is not always an easy task; in fact, it takes a lot more time and money than the methods that are used by most processors of herbs today.

Each plant has its own characteristics that must be taken into account in processing and standardizing its active ingredients. Most raw material suppliers of standardized herbs use a variety of chemicals, such as methyl chloride,
that denature some components of the original plant and are left in significant amounts in the end product.
The people who consume these herbs often have no idea that they are ingesting of Various toxic chemicals along with them. This doesn't work for me. Not only do natural processes of concentrating botanicals, like fermentation, allow the avoidance of chemicals, but they also preserve active enzymes and allow the full therapeutic potential of the whole plant to be realized.

In the development of Symbiotropin, I was led to the rain forest where I had done extensive work with botanicals in the past and had established valuable business connections. I discovered that a major pharmaceutical company was using a local botanical product in the development of a prescription secretagogue. This is not unusual as a large portion of prescription drugs are derived from plant sources by first isolating one active ingredient, denaturing it with a chemical side chain in order to patent it, then performing extensive clinical studies and finally submitting it, 21 million dollars later,
to the FDA for approval. Upon examination, I found that the "active" ingredient was enhanced by the plant's other components. Further, we found that a large amount of the activity of this ingredient was lost very rapidly (within 2 hours) after harvesting. One of the active ingredients in this plant is L-dopa, a potent stimulator of GH release. I had worked extensively with L-dopa in the past as a consultant on its delivery. L-dopa, used as an anti-aging drug and treatment for Parkinson's disease, is poorly absorbed and must be taken in super-physiologic doses (thousands of times what the body would produce in a day) in order to elicit a response. At high doses, L-dopa can produce side effects, but at lower doses it will stimulate GH release, improve mental performance, and improve symptoms of Parkinson's disease.
As was the case in all of my experience with other botanicals, the auxiliary substances in vicia faba, major enhanced
the activity and absorption of its naturally occurring L-dopa, so that it would become a highly active secretagogue at
lower doses and without the side effects of prescription L-dopa.

The effectiveness of Symbiotropin in Parkinson's patients has not been established through double blind clinical trials. However, there have been reports of rapid improvement in tremors and overall sense of well being. Growth hormone itself has produced improvements in Parkinson's disease; with the dual action of L-dopa and other secretagogues in Symbiotropin, and the lack of side effects, it's definitely worth a try for physician's to observe its -affect on patients
who suffer from this devastating disease.

Studies conducted on the effectiveness of various amino acid stimulants of growth hormone release have produced significant results. One test for GH secretory potential is the arginine loading test, but very large amounts are used-often intravenously. Other amino acids like ornithine, lysine, and glutamine have produced mixed results. In the development of Symbiotropin, I had to ask myself, "How could the response to these amino acids vary to such a large extent?"

As it turns out, the study on L-glutamine that produced the most significant elevation in GH administered the amino acid in a carbonated drink solution. How could carbonation make that much of a difference in the effectiveness of this amino acid in GH release? I had tested effervescent delivery with L-dopa and other substances in the past and found it to be highly effective in combination with Chaperone Molecules. With carbonation, I had been able to produce rapid and efficient delivery of sensitive compounds. In this case, I discovered that effervescent delivery assists in the delivery of all amino acids in Symbiotropin so that a greater and more consistent response can be derived with lower doses.

There are many receptors for these amino acids, so getting them to the right ones that stimulate GH release requires the use of Chaperone Molecules. In addition to protecting and delivering these amino acids, some Chaperone Molecules have insulin-regulating effects.

The importance of suppressing insulin in provoking GH release cannot be overstated. Blood sugar and insulin inhibit the release of growth hormone-this is a basic principle of the effectiveness of proper diet, fasting and exercise in stimulating GH. While consuming sugar and other carbohydrates in the diet will provoke insulin and inhibit GH release, there are other sugars, referred to as pharmaceutical saccharides that do not provoke insulin and are not metabolized as carbohydrates. In fact, when the right saccharides are used they do just the opposite-they help to regulate blood sugar and insulin. Some of these saccharides -like those in Symbiotropin- have a sweet taste, which eliminates the need for artificial or high carbohydrate sweeteners in flavoring the product.

I am not implying that insulin is the bad guy. In this highly complex system, we need insulin to promote the benefits of growth hormone. Studies show that GH fails to cause growth in animals lacking a pancreas and it also fails if carbohydrates (insulin provoking) are restricted from the diet. These studies reinforce our knowledge of insulin as a necessary catalyst in GH response and demonstrate that high levels of GH mean nothing in terms of results.
This is why I have concentrated on secretagogues, receptor site modulators, insulin regulation, and liver enzyme enhancers rather than GH injections.


As adequate availability of specific complex sugars, which only work in conjunction with insulin, is necessary for GH to be effective - it is interesting to note that bioengineered GH injectables significantly lower insulin levels - what will the long term effects be?

Upon examining the influences on GH and IGF-1, and looking further at their complex interaction with other hormones that are centrally controlled by the pituitary gland, it becomes apparent that the Methuselah factor is contained within the pituitary system. There are many ways in which we interfere with the proper functioning of this gland and other endocrine organs- including improper diet and exposure to environmental toxins that block receptors with their hormone-mimicking effects. At the same time, we have the tools to optimize the dietary influence on endocrine function and to unblock clogged receptors with the use of natural compounds. When we supply the proper peptides and other compounds, we "kick-start" optimal pituitary function, but we must not ignore pituitary feedback mechanisms that are affected by other hormones and the synergy that occurs when all hormones are addressed. It is a highly complex system, but as we develop a full understanding of the elusive Methuselah factor and its role in the maintenance of other hormones, perhaps we are creating the choice to live for hundreds of years.


A MESSAGE TO DOCTORS

There are over 110,000 genes in the human body-one million partial gene sequences have been identified. A new paradigm of pharmaceutical innovation is focusing on new hormones and microbial genes to broaden and accelerate the discovery of small molecule drugs. These new types of medicines include gene therapy, protein therapy, and anti-sense therapies. This method of small molecule drug discovery analyzes genes expressed only in diseased or target tissues and is catalyzing the change from current interdiction based medicine to gene based prevention.

With this research, we have gained access to therapeutic proteins that replace deficient, missing, or damaged hormones. Some of these synthesized peptides are currently under investigation as growth hormone secretagogues, but their naturally occurring counterparts are contained in Symbiotropin -an all natural GH secretagogue. Once we've identified the right peptides to use, the most challenging obstacles in attaining consistent and significant growth hormone release are absorption and delivery to the proper receptor sites. Our team has researched and developed an array of Chaperone Molecule delivery systems that address gastric absorption, transport through the bloodstream, and attachment to appropriate receptors.

Research on various synthesized peptide secretagogues has produced limited results in terms of IGF-1 formation and symptomatic improvement because they do not address insulin regulation, hepatic formation of IGF-1, or IGF-1 receptors. The pharmacologic effects of plant derived compounds are well documented in both human and animal clinical trials. These plant products possess structural similarities to endogenously produced hormones, which enhance their affinity to hormone receptors and steroid and prostaglandin dehydrogenases -making them effective adjuncts to a variety of hormone replacement therapies.

As we more fully understand the decline of endocrine function in the aging patient, we are recognizing the benefits of replacing a wider range Of hormones-where lower doses produce a greater overall benefit. Central to HRT response is management of growth hormone, insulin, and IGF-1. These hormones potentiate the function of estrogen, testosterone, progesterone, T3, and other hormones. Unlike these other hormones, which decline in production with age, growth hormone continues to be produced in significant amounts right into old age. The challenge in restoring youthful levels of GH is not increasing production or injecting the hormone itself, but releasing it from its sequestered state.
We now know how to unlock the gates that keep GH from circulating.

Studies on GH injections repeatedly demonstrate its effectiveness at reversing signs of aging by improving body composition, increasing bone density, reducing wrinkles, restoring hair, improving ,cardiac output, reducing cholesterol, and improving 'vision and memory. In addition, our clinical observations with Symbiotropin have yielded swift and significant improvement in diabetes and high blood pressure -even in patients whose symptoms were not able to be controlled with standard treatments. Insulin and IGF-1 regulation is an integral part of managing many of the signs and symptoms of aging.

As the FDA has recently approved growth hormone therapy for adults who are deficient, which includes most people over the age of 40, we are coming closer to the treatment of aging as a disease. In the replacement of deficient hormones, it is incumbent upon us to use the safest and most effective forms of these hormones. We are not limited to synthetic hormones that the body does not recognize and metabolize as its own, and which are associated with serious side effects. There are natural, safe, and effective forms of estrogen, progesterone, testosterone, thyroid hormone, DHEA, and other hormones that are identical to our own hormones. These hormones are available in dosage forms that maximize bioavailability and maintain effectiveness at physiologic doses. If our goal is to replace missing hormones,
why shouldn't we replace them naturally? What could be more natural than utilizing the growth hormone that continues
to be produced by our own pituitary?

                                                                                                                         -James Jamieson
 

"The Cancer Center (1-800-720-8933; cancernet.com) has had first hand confirmatory experience that Lissoni's reports from Italy asserting efficacy for cancer treatment of combined interleukin-2 (IL-2) and melatonin for many forms of adult cancer are valid. We believe immunotherapy has now advanced to the degree that it is a lifesaving, albeit less well studied, alternative to conventional cytotoxic chemotherapy for many patients, including 'those with adenocarcinoma of colon, pancreatic, breast, or lung origin. Once natural killer (NK) lymphocytes have reached two or three times the normal level, we have found [Symbiotropin] very useful to reduce the malaise often associated with high blood levels of NK cells. We have instances where the addition of [Symbiotropin] to (IL-2) therapy allowed us to restore debilitated previous recipients of combination chemotherapy and allowed continued use of (IL-2) and was associated with continued shrinkage of the cancer as evidenced by successive drops in serologic markers such as CEA or BR27.29."

-R. Arnold Smith, Jr., M.D.
S. North Central Mississippi Regional Cancer Center

J.M., Female, Age 71

Began taking Symbiotropin and within one week lost three pounds. Continued weight loss of three pounds per week throughout first cycle. Patient reported increased energy, increased sense of mental well-being, and deeper, more peaceful sleep. Skin appears softer and wrinkles are diminishing. Age spots diminishing.

L C, Female, Age 48

History of severe cardiomyopathy and hypertension. Treatment with other therapies provided some improvement, however cardiovascular function continued to deteriorate. With Symbiotropin, her energy level immediately increased. Shortness of breath decreased dramatically. She reports increased energy and sense of well-being. Several of her medications have been eliminated, including an ACE inhibitor; she continues to improve rapidly.

B.N., Male, Age 63

Overweight, heavy smoker, with cardiovascular disease and pulmonary distress. Had been treated with chelation therapy with some improvement. Within four weeks of Symbiotropin therapy, breathing was greatly improved. Lessened shortness of breath allows him to exercise to a much greater extent. His blood pressure has been significantly reduced.

PC, Female, Age 46

Heavy smoker with total hysterectomy performed in early 30's with subsequent hormone replacement therapy (HRT).
HRT did not control her hot flashes, sleeplessness, and anxiety. With Symbiotropin therapy, she made dramatic improvement in these, and related menopausal symptoms to the extent that she was able to reduce her dose of estrogen and Progestin while remaining symptom free. In,' addition, she reported improvement in other areas including improved energy.

G.F., Female, Age 65

History of being depressed and overweight. No long-term success with previous treatments. After onset of Symbiotropin therapy, she experienced weight loss of 2 pounds per week. Reports more energy and tremendous improvement in mental outlook and anxiety.

L.J., Male, Age 55

Prior to Symbiotropin, this patient was overweight and experienced reduced energy and sexual potency. After onset of Symbiotropin, he has reported deeper and sounder sleep at night, which has eliminated his need for napping during the day. He has improved stamina and is able to exercise more vigorously. He reports significant improvement sexual potency and has experienced continued weight loss.

 

"I weighed 300 lbs. and had been on insulin for almost five years... I was using a total of 175 units of 70130 insulin everyday.. my doctor added some glucophage... over the last two months I used Symbiotropin 5 nights a week, lost 50 lbs, and dropped insulin requirements to only 10 units a day! I'm going to keep using [Symbiotropin]... I was on glucophage before & it didn't help. I know what is causing my improvement. Thank you!

-D.J.

_______________________________

Now I have an overall healthy appearance and feeling of well-being.

- L.M. (Male, Age 75)

I have been on the Symbiotropin for the past four months... I have so much more energy now, I feel younger,
I look younger, I have less pains... I appreciate the difference it has made in my life.

- R.B., Male

Thank you so much for suggesting the Symbiotropin. I have been on the product for three months,
I have never felt better. My energy level is way up, my age spots are gone, I feel great...

R.S., Male

_______________________________

 

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